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DTSTART:20241103T020000
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UID:calendar.1774.events_uoft_date.0@www.psych.utoronto.ca
CREATED:20250203T162340Z
DESCRIPTION:\nWhen and Where: \nMonday, February 10, 2025 4:00 pm to 5:00
  pm \n Psychology Lounge; Room SS4043 \n Sidney Smith Hall \n 100 St. Geo
 rge Street \n\nSpeakers \nDr. Caleb Browne. Scientist, Centre for Addicti
 on and Mental Health Assistant. Professor, Department of Psychiatry, Uni
 versity of Toronto. \n\nDescription: \nNeural mechanisms underlying the de
 velopment of substance use disorder and relapse vulnerabilitySubstance use
  disorder (SUD) devastates lives and places a significant burden on the he
 althcare system. Despite its prevalence, effective treatment options rema
 in limited, and the chronically relapsing nature of SUD makes long-term a
 bstinence exceptionally difficult to achieve. This talk will present a ser
 ies of preclinical studies aimed at deepening our understanding of neural 
 mechanisms that drive the development and maintenance of SUD. First, I wi
 ll describe a neural substrate within the nucleus accumbens – a crucial hu
 b of the brain’s reward circuit – that enables drugs of abuse to hijack ne
 ural function and disrupt naturalistic goal-directed behavior. I will then
  outline molecular adaptations that support long-lasting relapse vulnerabi
 lity in a mouse model of opioid use disorder, with a focus on an epigenet
 ic mechanism in the ventral hippocampus – an important interface between m
 emory and motivation. These studies integrate in vivo two-photon calcium i
 maging, intravenous drug self-administration, RNA sequencing, bioinform
 atic analyses, and CRISPR-mediated gene regulation, forming a comprehens
 ive pipeline that has enabled us to generate new insights into how drugs o
 f abuse access and disrupt brain circuits and behaviour. Further, our fin
 dings offer novel avenues for developing much-needed therapeutic intervent
 ions to combat SUD.If you are unable to attend in person, please join on 
 Zoom.To request an individual meeting with the speaker, please contact Ka
 ori Takehara. \n100 St. George Street \n\nCategories \n Brain and Behaviou
 r Seminar Series \n\nAudiences \n All
DTSTART;TZID=America/New_York:20250210T160000
DTEND;TZID=America/New_York:20250210T170000
LAST-MODIFIED:20250203T165504Z
LOCATION:100 St. George Street
SUMMARY:Brain and Behaviour Seminar Series
URL;TYPE=URI:https://www.psych.utoronto.ca/events/brain-and-behaviour-semin
 ar-series-feb-10
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