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DTSTART:20251102T020000
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UID:calendar.1942.events_uoft_date.0@www.psych.utoronto.ca
CREATED:20260226T154834Z
DESCRIPTION:\nWhen and Where: \nThursday, April 09, 2026 11:00 am to 1:00
  pm \n SW403 \n University of Toronto Scarborough \n Joan Foley Hall, Mil
 itary Trail, Scarborough, ON M1C 1A4 \n\nSpeakers \nGiannina Descalzi, 
 Assistant Professor, Department of Biomedical Sciences, University of Gu
 elph \n\nDescription: \nOne in four Canadians over the age of 15 suffers f
 rom chronic pain, a condition that is a major risk factor for anxiety and
  depression. Our understanding of the molecular mechanisms involved is inc
 omplete, and there is a woeful lack of efficacious treatments, with less
  than half of all people suffering from chronic pain reporting any control
  of their pain. Moreover, although most people suffering from chronic pai
 n are women and other people with ovaries, preclinical studies have almos
 t exclusively used male rodent models (>80%), resulting in a major gap in
  our understanding. Neuroimaging studies of people with chronic pain provi
 de an opportunity to employ reverse translational strategies to test hypot
 heses of pain chronification. Repeatedly, neuroimaging studies have ident
 ified structural and functional changes to multiple regions of the emotion
 -pain brain network, including the anterior cingulate cortex (ACC), nucl
 eus accumbens (NAc), and amygdala, in people suffering from chronic pain
 . Accordingly, numerous studies of analogous brain regions in rodent mode
 ls have also revealed changes in neuronal excitability and structure. With
 in this network, neuroplasticity of the rodent ACC has emerged as a criti
 cal step for chronic pain development. This talk will combine behavioural\
 , molecular, and bioinformatic approaches to investigate neuroplastic cha
 nges within the cingulate cortex in mouse models of chronic pain. A major 
 focus will be on glial-neuronal interactions, and the critical role astro
 cyte-neuronal metabolic coupling plays in pain-induced neuroplasticity. Se
 x differences will be highlighted, and mechanisms promoting pain chronifi
 cation will be covered.Hybrid Zoom link: https://utoronto.zoom.us/j/849174
 42572Passcode: 786860 To request an individual meeting with the speaker, 
 please contact Maithe Arruda-Carvalho (m.arrudacarvalho@utoronto.ca).Visit
  https://www.takeharalab.com/bbseminar for further information. \nJoan Fol
 ey Hall, Military Trail, Scarborough, ON M1C 1A4 \n\nCategories \n Brai
 n and Behaviour Seminar Series \n\nAudiences \n All
DTSTART;TZID=America/New_York:20260409T110000
DTEND;TZID=America/New_York:20260409T130000
LAST-MODIFIED:20260319T145353Z
LOCATION:Joan Foley Hall, Military Trail, Scarborough, ON M1C 1A4
SUMMARY:Molecular and cellular mechanisms promoting chronic pain developmen
 t
URL;TYPE=URI:https://www.psych.utoronto.ca/events/molecular-and-cellular-me
 chanisms-promoting-chronic-pain-development
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