Analyses and Interpretation of Connectomes: Insights from the developing C. elegans central nervous system

When and Where

Monday, February 25, 2019 4:00 pm to 5:00 pm
Room 560A
Sidney Smith Hall
100 St. George Street


MEI ZHEN, Department of Molecular Genetics; Department of Physiology, University of Toronto


Abstract: The nervous system is dynamic, with continuous growth throughout life. Rules for this plasticity however are poorly characterized, because a circuit-level comparison at multiple developmental time points is missing. Using serial-section electron microscopy, we have mapped the synaptic connectivity in the central nervous system for eight C. elegans, from newly hatched larva to adults. These datasets reveal unexpected notions, such as the prevalence of individual variability of isogenic individuals, and an early establishment of the core decision-making circuits. I further summarize current status and future directions for the analyses andinterpretation for connectomics studies.

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100 St. George Street